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Blanka
Cammy
This match might be Luke's most difficult matchup. OD Spin Knuckle goes through Luke's sandblast too easily, cannon strike also can go through his sandblast, and all around she has better normals than Luke and better reach. Luke's only saving grace is his damage is higher using less resources. Overall, you want to play this match very carefully and sparingly use sandblast. Use 2LP to check the spin knuckles instead of drive impact so that you don't get baited. Use rising uppercut from a full crouch to beat the cannon strike, but make sure you don't get baited because she can use the LK version at the right distance to make it whiff. In general, don't fall for spacing traps used to beat pre-emptive buttons; meaning for instance maybe she will do some light chain sequence, and then right after go for a cannon strike to beat any of Luke's buttons like 2MK, 5MK, 5MP etc. Be cautious in these moments and don't press right away.
The match definitely isn't horrible, it is winnable but just need to work hard in the neutral game and play carefully.
Chun-Li
Dee Jay
Dhalsim
E.Honda
Guile
Jamie
JP
Juri
slightly difficult match for Luke mainly due to Juri having better overall normals. I've seen complaints from both Juri players and Luke players, so let's just go with 5-5. Juri's 2MK is one of the best in the game, if you couple that with Luke's very subpar sweep, it can be difficult to whiff punish this character. Often times it's not even worth it to try to whiff punish because you'll end up getting punished back for the attempt. Luke's saving grace is his sandblast as Juri doesn't have good antifireball moves like Cammy for example. Luke can also prevent Juri from getting stocks due to sandblast. You'll definitely want to look for jumps and drive impacts which they may go for to get around sandblast. Whiff punish 5HK with Luke's 5HP into 214P perfect. Against 2MK, often times a pre-emptive sandblast is the best option, otherwise be cautious when trying to sweep it. Against drive rush, depending on the spacing, 5MK will work very well against Juri's DR 5MP and 5MK. From very far, youc an use 5HK from Luke, and from very close 2LP/5LK.
If Juri's fireball is out, it's often best to just keep walking back and get away from it, if you get too close it puts you into drive rush mixup situation and you'll have to guess. You can parry it and then go for a reaction drive reversal as well. If you react to Juri's Fuha (the move to get stores) you can use OD sandblast full version to punish her.
Ken
Probably a fair match, although I have seen Luke's complain about it. Ken has really good corner carry, side switches, better mixups (run overhead/low, crossup OD Tatsu) and good pressure strings using jinrai kicks. Ken has a slightly better low forward due to the 7f vs Luke's 8f. Luke has a significantly better fireball, his mids such as 5MP and 5HP are some of the best in the game, and his overall defensive normals like 5MK and 2MP can make it difficult for a ken to approach. Overall Luke has slightly better neutral due to his sandblast and the reach on his 5MP, 5HP and his defensive normals, use them when you can but be careful not to whiff. You'll definitely want to make sure to block Ken's 2MK because it will be his main normal that he will use to go into drive rush.
You can punish the jinrai kicks based on the version and the spacing it was done at, except if they're spaced at the tip. Use Luke's sweep to punish a whiffed Ken 2MK, against Ken's 5MK and 5HP, use 5MP or if you're on point, 5HP into 214LP perfect for huge damage.
Kimberly
Lily
Luke
Manon
Marisa
Ryu
Zangief